Martentoxin: a unique ligand of BK channels / 生理学报
Acta Physiologica Sinica
;
(6): 355-364, 2012.
Artículo
en Inglés
| WPRIM
| ID: wpr-333191
ABSTRACT
The large-conductance calcium-activated potassium (BK) channels distributed in both excitable and non-excitable cells are key participants in a variety of physiological functions. By employing numerous high-affinity natural toxins originated from scorpion venoms the pharmacological and structural characteristics of these channels tend to be approached. A 37-residue short-chain peptide, named as martentoxin, arising from the venom of the East-Asian scorpion (Buthus martensi Karsch) has been investigated with a comparatively higher preference for BK channels over other voltage-gated potassium (Kv) channels. Up to now, since the specific drug tool probing for clarifying structure-function of BK channel subtypes and related pathology remain scarce, it is of importance to illuminate the underlying mechanism of molecular interaction between martentoxin and BK channels. As for it, the current review will address the recent progress on the studies of pharmacological characterizations and molecular determinants of martentoxin targeting on BK channels.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Péptidos
/
Venenos de Escorpión
/
Química
/
Secuencia de Aminoácidos
/
Canales de Potasio de Gran Conductancia Activados por el Calcio
/
Ligandos
Límite:
Humanos
Idioma:
Inglés
Revista:
Acta Physiologica Sinica
Año:
2012
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS