Relationship between tumor necrosis factor A-308 gene polymorphism and aggressive periodontitis / 中华口腔医学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the relationship between tumor necrosis factor (TNF) A-308 gene polymorphism and aggressive periodontitis (AgP).</p><p><b>METHODS</b>Anti-coagulated peripheral blood samples were obtained from 64 AgP patients, and 78 healthy controls (H). Genomic DNA was extracted from each sample. The TNF A-308 gene polymorphism was detected by standard polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. Data were analyzed by SAS statistical software.</p><p><b>RESULTS</b>There was no significant difference in distribution of TNF A-308 genotype between AgP patients and healthy controls. But the ORs for genotype GA and allele A were 22.2 and 16.1 respectively in non-smoking male AgP patients.</p><p><b>CONCLUSIONS</b>The TNF A-308 genotype GA and allele A may be associated with AgP susceptibility in Chinese males.</p>