Expression of lipopolysaccharide receptors CD14 and TLR4 in a model of rat molar apical periodontitis / 中华口腔医学杂志
Chinese Journal of Stomatology
;
(12): 148-149, 2007.
Artículo
en Chino
| WPRIM
| ID: wpr-333382
ABSTRACT
<p><b>OBJECTIVE</b>To characterize the expression of lipopolysaccharide (LPS) receptors-CD14 and TLR4 in rat peri-radicular tissue and to investigate the signal transduction pathway of LPS and its receptors in periapical periodontitis.</p><p><b>METHODS</b>After establishment of a model of rat molar LPS-induced apical periodontitis, CD14 and TLR4 expression in healthy and inflammatory periapical tissue were determined by immunohistochemistry.</p><p><b>RESULTS</b>CD14 and TLR4 were not detected in healthy periapical tissue but strongly positive in inflammatory periapical tissue. Positive cells were mostly monocytes/macrophages.</p><p><b>CONCLUSIONS</b>CD14 and TLR4 may play an important role in the pathogenesis of periapical periodontitis, probably via immune cells such as monocytes/macrophages and neutrophils.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Periodontitis Periapical
/
Transducción de Señal
/
Lipopolisacáridos
/
Ratas Sprague-Dawley
/
Receptores de Lipopolisacáridos
/
Modelos Animales de Enfermedad
/
Receptor Toll-Like 4
/
Toxicidad
/
Metabolismo
Límite:
Animales
Idioma:
Chino
Revista:
Chinese Journal of Stomatology
Año:
2007
Tipo del documento:
Artículo
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