Partial liquid ventilation decreases tissue and serum tumor necrosis factor-α concentrations in acute lung injury model of immature piglet induced by oleic acid / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 123-128, 2012.
Artículo
en Inglés
| WPRIM
| ID: wpr-333529
ABSTRACT
<p><b>BACKGROUND</b>Pediatric patients are susceptible to lung injury. Acute lung injury in children often results in high mortality. Partial liquid ventilation (PLV) has been shown to markedly improve oxygenation and reduce histologic evidence of injury in a number of lung injury models. This study was designed to examine the hypothesis that PLV would attenuate the production of local and systemic tumor necrosis factor (TNF)-α in an immature piglet model of acute lung injury induced by oleic acid (OA).</p><p><b>METHODS</b>Twelve Chinese immature piglets were induced acute lung injury by OA. The animals were randomly assigned to two groups of six animals, (1) conventional mechanical ventilation (MV) group and (2) PLV with 10 ml/kg FC-77 group.</p><p><b>RESULTS</b>Compared with MV group, the PLV group had better cardiopulmonary variables (P < 0.05). These variables included heart rate, mean blood pressure, blood pH, partial pressure of arterial oxygen (PaO2), PaO2/inspired O2 fraction (FiO2) and partial pressure of arterial carbon dioxide (PaCO2). PLV reduced TNF-α levels both in plasma and tissue compared with MV group (P < 0.05).</p><p><b>CONCLUSION</b>PLV provides protective effects against TNF-α response in OA-induced acute lung injury in immature piglets.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Porcinos
/
Terapéutica
/
Sangre
/
Factor de Necrosis Tumoral alfa
/
Ácido Oléico
/
Ventilación Liquida
/
Toxicidad
/
Lesión Pulmonar Aguda
/
Animales Recién Nacidos
/
Metabolismo
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Inglés
Revista:
Chinese Medical Journal
Año:
2012
Tipo del documento:
Artículo
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