The impact of radiotherapy on clinical outcomes in parameningeal rhabdomyosarcoma
Radiation Oncology Journal
;
: 290-296, 2016.
Artículo
en Inglés
| WPRIM
| ID: wpr-33372
ABSTRACT
PURPOSE:
Radiotherapy (RT) is considered a mainstay of treatment in parameningeal rhabdomyosarcoma (PM-RMS). We aim to determine the treatment outcomes and prognostic factors for PM-RMS patients who treated with RT. In addition, we tried to evaluate the adequate dose and timing of RT. MATERIALS ANDMETHODS:
Twenty-two patients with PM-RMS from 1995 to 2013 were evaluated. Seven patients had intracranial extension (ICE) and 17 patients had skull base bony erosion (SBBE). Five patients showed distant metastases at the time of diagnosis. All patients underwent chemotherapy and RT. The median radiation dose was 50.4 Gy (range, 40.0 to 56.0 Gy).RESULTS:
The median follow-up was 28.7 months. Twelve patients (54.5%) experienced failure after treatment; 4 local, 2 regional, and 6 distant failures. The 5-year local control (LC) and overall survival (OS) were 77.7% and 38.5%, respectively. The 5-year OS rate was 50.8% for patients without distant metastases and 0% for patients with metastases (p 22 weeks) of RT was related to a higher rate of local failure (40.0%).CONCLUSION:
RT resulted in a higher rate of local control in PM-RMS. However, it was not extended to survival outcome. A more effective treatment for PM-RMS is warranted.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Radioterapia
/
Rabdomiosarcoma
/
Estudios de Seguimiento
/
Base del Cráneo
/
Diagnóstico
/
Quimioterapia
/
Hielo
/
Meninges
/
Metástasis de la Neoplasia
Tipo de estudio:
Estudio diagnóstico
/
Estudio observacional
/
Estudio pronóstico
Límite:
Humanos
Idioma:
Inglés
Revista:
Radiation Oncology Journal
Año:
2016
Tipo del documento:
Artículo
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