Effect of aspirin on pulmonary hypertension in rat during chronic hypoxia and hypercapnia / 中国应用生理学杂志

ABSTRACT

<p><b>AIM</b>To study the effect of aspirin on chronic hypoxia and hypercapnic pulmonary hypertension.</p><p><b>METHODS</b>SD rats were randomly divided into normal control group (A), hypoxic hypercapnic group (B), hypoxic hypercapnia + aspirin group (C). The concentration of TXB2 and 6-keto-PGF1alpha in plasma and in lung were detected by the technique of radioimmunology.</p><p><b>RESULTS</b>(1) mPAP was significantly higher in B group than those of A and C group. Differences of mCAP were not significant in three groups. (2) Light microscopy showed that WA/TA (vessel wall area/total area) and PAMT (the thickness of medial smooth cell layer) were significantly higher in B group than those of A and C group. (3) The concentration of TXB2 and 6-keto-PGF1alpha in plasma and lung as well as the ratio of TXB2/6-keto-PGF1alpha were significantly higher in rats of B group than those of A and C group.</p><p><b>CONCLUSION</b>Aspirin may inhibit hypoxic hypercapnia pulmonary hypertension and pulmonary vessel remodeling.</p>