Effect of CoCl2 pretreatment on Na + and K+ currents of the rat hippocampal neurons after acute hypoxia / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 250-252, 2003.
Artículo
en Chino
| WPRIM
| ID: wpr-333786
ABSTRACT
<p><b>AIM</b>To study effect of CoCl2 pretreatment on the voltage-gated Na+ and K+ currents of the rat hippocampal neurons after acute hypoxia.</p><p><b>METHODS</b>Primarily cultured hippocampal neurons were divided into CoCl2 pretreated and non-pretreated groups. Patch clamp whole cell recording technique was used to examine Na+ and K+ currents of the hippocampal neurons.</p><p><b>RESULTS</b>After acute hypoxia, I(Na) and I(K) of the hippocampal neurons were significantly decreased and the threshold of I(Na) was right-shifted. Pretreatment of the neurons with CoCl2 inhibited the reduction of I(Na) and I(K).</p><p><b>CONCLUSION</b>CcCl2 pretreatment alleviates the acute hypoxia-induced changes of I(Na) and I(K), which may be one of the mechanisms for the protective effect of CoCl2 on neurons.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Canales de Potasio
/
Canales de Sodio
/
Hipoxia de la Célula
/
Ratas Wistar
/
Cobalto
/
Técnicas de Placa-Clamp
/
Biología Celular
/
Hipocampo
/
Animales Recién Nacidos
Límite:
Animales
Idioma:
Chino
Revista:
Chinese Journal of Applied Physiology
Año:
2003
Tipo del documento:
Artículo
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