Clinicopathologic features, prognosis and etiology of primary non-Hodgkin lymphoma of bone / 中华病理学杂志
Chinese Journal of Pathology
; (12): 90-93, 2007.
Article
en Zh
| WPRIM
| ID: wpr-333962
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the clinicopathologic features, prognostic indicators and possible etiology of primary non-Hodgkin lymphoma of bone (PNHLB).</p><p><b>METHODS</b>The clinicopathologic features of 17 cases of PNHLB were reviewed. In-situ hybridization for Epstein-Barr virus early RNA (EBER) and polymerase chain reaction for bcl-2/JH gene rearrangement were performed using paraffin-embedded materials. The correlation between serum lactic dehydrogenase level, treatment options, international prognostic indicator (IPI) and immunophenotype with clinical outcome were analyzed.</p><p><b>RESULTS</b>The majority of the 17 cases studied was diffuse large B-cell lymphoma (94.1%). The 5-year survival rate was 68.8%. Unfavorable prognostic factors included high-risk IPI (P = 0.031) and bcl-2 overexpression (P = 0.028). Treatment options and expression of CD10, MUM-1 or bcl-6 did not correlate with clinical outcome (P > 0.05). Only 1 patient was positive for EBER, as demonstrated by in-situ hybridization.</p><p><b>CONCLUSIONS</b>The clinical outcome of PNHLB is relatively favorable. IPI and bcl-2 expression may serve as useful prognostic indicators. EBV is likely not related to pathogenesis of this type of lymphoma.</p>
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Asunto principal:
Patología
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Pronóstico
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Proteínas Ribosómicas
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Neoplasias Óseas
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Linfoma no Hodgkin
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Reordenamiento Génico
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Neprilisina
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Tasa de Supervivencia
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Inmunofenotipificación
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Linfoma de Células B Grandes Difuso
Tipo de estudio:
Etiology_studies
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Prognostic_studies
Límite:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Pathology
Año:
2007
Tipo del documento:
Article