Promoter Methylation of p16 Gene in Cervical Cancer / 부인종양
Korean Journal of Gynecologic Oncology
; : 21-26, 2005.
Article
en En
| WPRIM
| ID: wpr-33414
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE: To investigate the promoter methylation status in the p16 gene in primary cervical cancer and to analyze the relationships between the clinicopathologic parameters and the methylation status of p16 gene. METHODS: Promoter methylation was evaluated by using a methylation-specific polymerase chain reaction in 78 cervical cancer tissues and 24 control non-neoplastic cervical tissues. Clinicopathologic parameters were obtained from medical records and the relationships between the discrete variables and the methylation status were evaluated. RESULTS: The frequency of the promoter methylation of p16 in cervical cancer was 57.0% (45/78). Primary cervical cancer had a significantly higher methylation frequency for p16 gene as compared to a control non-neoplastic cervix (p<0.0001). Higher stage cancers exhibited an increased promoter methylation frequency for p16 (45.6% in stage Ib, 58.3% in stage IIa, 88.2% in stage IIb, and 66.7% in stage IIIb, p=0.0125). CONCLUSION: Our results suggest that promoter methylation of p16 is a frequent event in cervical carcinogenesis and has a potential clinical application as markers for cancer progression and prediction of prognosis.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Pronóstico
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Neoplasias del Cuello Uterino
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Cuello del Útero
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Registros Médicos
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Reacción en Cadena de la Polimerasa
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Genes p16
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Carcinogénesis
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Metilación
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Korean Journal of Gynecologic Oncology
Año:
2005
Tipo del documento:
Article