A clinical research on oxymatrine for the treatment of chronic hepatitis B / 中华肝脏病杂志
Chinese Journal of Hepatology
; (12): 280-281, 2002.
Article
en Zh
| WPRIM
| ID: wpr-334227
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the clinical effect of oxymatrine on chronic viral hepatitis B and to look for new methods for treating hepatitis B.</p><p><b>METHODS</b>Multi-center, controlled study was used. In this study, 196 patients were allocated to oxymatrine, oxymatrine with Ara-AMP, IFN-a1b, and glucose groups to observe ALT, AST and viral marker changes.</p><p><b>RESULTS</b>At the end of treatment, the rate of normal ALT, the negative rate of HBV DNA and HBeAg, and the positive rate of HBeAb were similar in oxymatrine, oxymatrine with Ara-AMP, and IFN-a1b groups. It was higher than that of glucose group. After 12 months follow up, the total effective rate is 40.8%, 60.8% and 43.1% in oxymatrine, oxymatrine with Ara-AMP, and IFN-a1b groups, respectively.</p><p><b>CONCLUSIONS</b>Oxymatrine, oxymatrine with Ara-AMP, and IFN-a1b are effective to treat hepatitis B with a good negative rate of HBV DNA and HBeAg and positive rate of HBeAb.</p>
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Antivirales
/
Quinolizinas
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Hepatitis B Crónica
/
Usos Terapéuticos
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Quimioterapia
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Alcaloides
Límite:
Adolescent
/
Adult
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Hepatology
Año:
2002
Tipo del documento:
Article