Study on the association of ABCA1 gene common variants with the risk of coronary atherosclerotic heart disease / 中华心血管病杂志
Chinese Journal of Cardiology
;
(12): 627-630, 2005.
Artículo
en Chino
| WPRIM
| ID: wpr-334643
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association of R219K and M883I polymorphisms of ATP binding cassette transporter 1 gene with lipid metabolism and the susceptibility to coronary atherosclerotic heart disease in Chinese population.</p><p><b>METHODS</b>Genotypes were determined by PCR-restriction fragment length polymorphism and Primer introduced restriction analysis-PCR techniques, respectively, in 248 unrelated CHD-free controls and 224 CHD cases.</p><p><b>RESULTS</b>Smoking, high blood pressure and high serum glucose were independent risk factors for CHD. Multivariate logistic regression analysis revealed that individuals carrying at least one 219K variant allele (RK + KK genotypes) had a significantly decreased risk for CHD (adjusted OR = 0.41; 95% CI = 0.27-0.61) compared with the wild-type genotype (219RR) and only 883II homozygotes displayed a decreased risk for CHD (adjusted OR = 0.54; 95% CI = 0.26-1.11) compared with 883MM and 883MI genotypes. Furthermore, compared with individuals with both wild genotypes (219 RR and 883 MM or 883 MI) other individuals with all other assembly genotypes had a significantly decreased risk (adjusted OR = 0.39, 95% CI = 0.26-0.60). Plasma HDL-C in 219K allele carriers were markedly higher than those in 219 K non-carriers in controls (P = 0.037).</p><p><b>CONCLUSION</b>The ABCA1 R219K polymorphism may be involved in the variability of serum HDL-C and the susceptibility to coronary artery disease.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Enfermedad de la Arteria Coronaria
/
Estudios de Casos y Controles
/
Transportadoras de Casetes de Unión a ATP
/
Predisposición Genética a la Enfermedad
/
Polimorfismo de Nucleótido Simple
/
Transportador 1 de Casete de Unión a ATP
/
Genética
Tipo de estudio:
Estudio de etiología
/
Estudio observacional
/
Factores de riesgo
Límite:
Anciano
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Cardiology
Año:
2005
Tipo del documento:
Artículo
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