Effects of fluvastatin on blood levels of inflammatory cytokines in patients with unstable angina undergoing percutaneous coronary intervention / 中华心血管病杂志
Chinese Journal of Cardiology
;
(12): 320-322, 2005.
Artículo
en Chino
| WPRIM
| ID: wpr-334710
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of fluvastatin on blood levels of c-reactive protein (CRP), tumor necrosis factor alpha (TNFalpha) and cardiac troponin I (cTnI) in patients with unstable angina undergoing percutaneous coronary intervention (PCI).</p><p><b>METHODS</b>Sixty patients who underwent PCI from July 2002 to April 2004 in our hospital were randomized into two groups control group; fluvastatin group (40 mg/d). Serum levels of CRP, TNFalpha and cTnI were measured before and after two weeks treatment (in the early morning of the procedure) and at 24 hours after the procedure.</p><p><b>RESULTS</b>The serum levels of CRP, TNFalpha and cTnI in fluvastatin group were distinctly lower than those in control group before (P < 0.01) and after the procedure (P < 0.01), respectively.</p><p><b>CONCLUSION</b>The result suggested that PCI could lead to a detectable increase in serum levels of CRP, TNFalpha and cTnI in patients with coronary heart disease; Fluvastatin could significantly decrease the serum levels of CRP, TNFalpha and cTnI in patients with coronary heart disease; Fluvastatin could also decrease the serum levels of CRP, TNFalpha and cTnI in patients with PCI.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Sangre
/
Proteína C-Reactiva
/
Ácidos Grasos Monoinsaturados
/
Factor de Necrosis Tumoral alfa
/
Troponina I
/
Usos Terapéuticos
/
Quimioterapia
/
Indoles
/
Angina Inestable
/
Metabolismo
Tipo de estudio:
Ensayo Clínico Controlado
Límite:
Humanos
Idioma:
Chino
Revista:
Chinese Journal of Cardiology
Año:
2005
Tipo del documento:
Artículo
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