Molecular interaction between PrP protein and the signal protein 14-3-3 beta / 病毒学报
Chinese Journal of Virology
;
(6): 208-212, 2009.
Artículo
en Chino
| WPRIM
| ID: wpr-334749
ABSTRACT
The molecular interaction between PrP and 14-3-3 beta and the possible interactional domain between two proteins were studied by co-immunoprecipitation, pull down and FRET assays. The results showed that PrP protein could interact with 14-3-3 beta in vitro and in vivo. The domain which responded for the interaction was located at C-terminal of PrP (amino acid residues 106 to 126). This study of the interaction between PrP and 14-3-3 protein further provided the insight into the potential role of 14-3-3 in the biological function of PrP and the pathogenesis of prion disease.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Unión Proteica
/
Encéfalo
/
Priones
/
Células HeLa
/
Transferencia Resonante de Energía de Fluorescencia
/
Proteínas 14-3-3
/
Inmunoprecipitación
/
Metabolismo
Límite:
Animales
/
Humanos
Idioma:
Chino
Revista:
Chinese Journal of Virology
Año:
2009
Tipo del documento:
Artículo
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