Surveillance for occult HBV infection and HBsAg variants in blood donors / 病毒学报
Chinese Journal of Virology
; (6): 178-184, 2009.
Article
en Zh
| WPRIM
| ID: wpr-334754
Biblioteca responsable:
WPRO
ABSTRACT
Occult hepatitis B virus (HBV) infection status of blood donors in a southern city in China was investigated by immunological assays and nucleic acid testing. Overall, 17 (0.19%, 95% CI: 0.11%-0.30%) of the 9023 HBsAg negative samples were found to be positive for the presence of HBV DNA. "A" epitope sequences were obtained from 14 among them. Mutation(s) in aa124-aa147 existed in 6 (42.9%, 6/14) samples and 4 (66.7%, 4/6)were G145R mutation. Ratio of genotype C in occult donors (10/17) was statistically higher than HBs-positive donors (0/15, P<0.01), which implied that HBV genotype C leaded to occult infection more easily.
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Fisiología
/
Virología
/
Donantes de Sangre
/
Pruebas Inmunológicas
/
ADN Viral
/
China
/
Virus de la Hepatitis B
/
Epidemiología
/
Alineación de Secuencia
/
Clasificación
Tipo de estudio:
Diagnostic_studies
/
Screening_studies
Límite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
País/Región como asunto:
Asia
Idioma:
Zh
Revista:
Chinese Journal of Virology
Año:
2009
Tipo del documento:
Article