Expression of E-cadherin and beta-catenin in Bowen's disease and squamous cell carcinoma / 南方医科大学学报
Journal of Southern Medical University
; (12): 1245-1247, 2006.
Article
en Zh
| WPRIM
| ID: wpr-334950
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the involvement of E-cadherin-catenin adhesion system in Bowen's disease (BD) and cutaneous squamous cell carcinoma (SCC).</p><p><b>METHODS</b>Fifteen normal skin, 28 BD and 18 SCC specimens were stained with monoclonal antibodies against E-cadherin and beta-catenin. Evaluation of the staining results was performed with semi-quantification of the pattern and intensity of staining, percentage of positive cells, and cytoplasmic staining.</p><p><b>RESULT</b>Normal skins strongly expressed membranous E-cadherin and beta-catenin, but their expression was remarkably reduced in BD and SCC. Abnormal staining of beta-catenin was observed in the cytoplasm or cell nuclei of BD and SCC.</p><p><b>CONCLUSION</b>Abnormal expression of the E-cadherin/catenin complex is common in SCC and BD.</p>
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Patología
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Neoplasias Cutáneas
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Enfermedad de Bowen
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Inmunohistoquímica
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Carcinoma de Células Escamosas
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Cadherinas
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Beta Catenina
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Metabolismo
Límite:
Adult
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Aged
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Journal of Southern Medical University
Año:
2006
Tipo del documento:
Article