HLA-DM gene polymorphism in Cantonese with condyloma acuminata / 南方医科大学学报
Journal of Southern Medical University
; (12): 1014-1026, 2006.
Article
en Zh
| WPRIM
| ID: wpr-335005
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the polymorphism of HLA-DM gene in Cantonese patients with condyloma acuminata(CA) and determine the susceptible genetic factors of CA.</p><p><b>METHODS</b>DMA and DMB typing was performed in 98 Cantonese patients with CA and 93 healthy controls using restriction fragment length polymorphism method.</p><p><b>RESULTS</b>The gene frequencies of DMA*0101 and DMB*0101 were significantly higher in the patients than in the controls (P<0.05 and P<0.01, respectively), and gene frequency of DMA*0102 was lower in patients than in the controls (P<0.01). Genotype frequencies of HLA-DM showed no significant difference between CA patients and the controls (P>0.05).</p><p><b>CONCLUSION</b>DMA*0101 and DMB*0101 alleles may be the susceptibility genes or closely linked to the susceptibility gene in Cantonese patients with CA.</p>
Texto completo:
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Índice:
WPRIM
Asunto principal:
Polimorfismo Genético
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Condiloma Acuminado
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Antígenos HLA-D
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Predisposición Genética a la Enfermedad
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Frecuencia de los Genes
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Genética
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Genotipo
Límite:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Journal of Southern Medical University
Año:
2006
Tipo del documento:
Article