Generation of GABAergic interneuron-specific PGC-1α knockout mice / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 200-204, 2017.
Artículo
en Chino
| WPRIM
| ID: wpr-335156
ABSTRACT
<p><b>OBJECTIVE</b>To generate mice which are specific for peroxisomproliferator-activated receptor-γ coactivator-1(PGC-1α) knockout in the GABAergic interneuron.</p><p><b>METHODS</b>Conditional mice specific for PGC-1αwere introduced from the Jackson Laboratory, USA and initially inbred to obtain homozygote PGC-1αmice. The PGC-1αconditional mice were further crossed with Dlx5/6-Cre-IRES-EGFP transgenic mice to achieve specific knockout of PGC-1α in the GABAergic interneuron.</p><p><b>RESULTS</b>The offspring with specific knockout PGC-1α gene were successful for the generation of GABAergic interneuron, with the resulting genotype being PGC-1α.</p><p><b>CONCLUSION</b>The PGC-1αmice were obtained through a proper crossing strategy, which has provided a suitable platform for studying the function of PGC-1α in neuropsychiatric diseases.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Ratones Noqueados
/
Enfermedades Neurodegenerativas
/
Coactivador 1-alfa del Receptor Activado por Proliferadores de Peroxisomas gamma
/
Ácido gamma-Aminobutírico
/
Genética
/
Interneuronas
/
Metabolismo
Límite:
Animales
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Medical Genetics
Año:
2017
Tipo del documento:
Artículo
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