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Generation of GABAergic interneuron-specific PGC-1α knockout mice / 中华医学遗传学杂志
Chinese Journal of Medical Genetics ; (6): 200-204, 2017.
Artículo en Chino | WPRIM | ID: wpr-335156
ABSTRACT
<p><b>OBJECTIVE</b>To generate mice which are specific for peroxisomproliferator-activated receptor-γ coactivator-1(PGC-1α) knockout in the GABAergic interneuron.</p><p><b>METHODS</b>Conditional mice specific for PGC-1αwere introduced from the Jackson Laboratory, USA and initially inbred to obtain homozygote PGC-1αmice. The PGC-1αconditional mice were further crossed with Dlx5/6-Cre-IRES-EGFP transgenic mice to achieve specific knockout of PGC-1α in the GABAergic interneuron.</p><p><b>RESULTS</b>The offspring with specific knockout PGC-1α gene were successful for the generation of GABAergic interneuron, with the resulting genotype being PGC-1α.</p><p><b>CONCLUSION</b>The PGC-1αmice were obtained through a proper crossing strategy, which has provided a suitable platform for studying the function of PGC-1α in neuropsychiatric diseases.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Ratones Noqueados / Enfermedades Neurodegenerativas / Coactivador 1-alfa del Receptor Activado por Proliferadores de Peroxisomas gamma / Ácido gamma-Aminobutírico / Genética / Interneuronas / Metabolismo Límite: Animales / Femenino / Humanos / Masculino Idioma: Chino Revista: Chinese Journal of Medical Genetics Año: 2017 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Ratones Noqueados / Enfermedades Neurodegenerativas / Coactivador 1-alfa del Receptor Activado por Proliferadores de Peroxisomas gamma / Ácido gamma-Aminobutírico / Genética / Interneuronas / Metabolismo Límite: Animales / Femenino / Humanos / Masculino Idioma: Chino Revista: Chinese Journal of Medical Genetics Año: 2017 Tipo del documento: Artículo