Association of serum lipid profile with distant metastasis in breast cancer patients / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 129-131, 2012.
Artículo
en Chino
| WPRIM
| ID: wpr-335330
ABSTRACT
<p><b>OBJECTIVE</b>In order to investigate whether the presence of distant metastases is associated with serum lipid abnormalities.</p><p><b>METHODS</b>The fasting serum lipid profile and various clinicopathological data of 324 breast cancer patients with and without synchronous distant metastases were collected and analyzed. The serum lipid profile, including total cholesterol (TC), triglycerides (TG), low-density (LDL-C) and high-density lipoprotein cholesterol (HDL-C) was determined. The nutritional status, the serum albumin was measured and body mass index (BMI) was calculated. Univariate analysis and multiple logistic regression analysis were carried out to investigate the association of serum lipid profile with distant metastases.</p><p><b>RESULTS</b>Univariate analysis showed that the distant metastasis rate was significantly higher in the breast cancer patients with an higher level of serum TC, TG, LDL-C, and LDL-C/HDL-C ratio (P < 0.05). Multiple logistic regression analysis showed that higher serum levels of TC, LDL-C and LDL-C/HDL-C ratio were independent risk factors for distant metastasis in breast cancer (OR = 2.324, 2.648 and 4.862, respectively).</p><p><b>CONCLUSIONS</b>Hyperlipidemia is significantly associated with the distant metastasis in breast cancer patients. Monitoring of serum lipid profile may be helpful to predict the occurrence of distant metastasis in breast cancer patients.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Triglicéridos
/
Sangre
/
Neoplasias de la Mama
/
Albúmina Sérica
/
Índice de Masa Corporal
/
Colesterol
/
Estado Nutricional
/
Análisis Multivariante
/
Factores de Riesgo
Tipo de estudio:
Estudio de etiología
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Adulto
/
Anciano
/
Aged80
/
Femenino
/
Humanos
Idioma:
Chino
Revista:
Chinese Journal of Oncology
Año:
2012
Tipo del documento:
Artículo
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