Changes of dopamine transporter function in striatum during acute morphine addiction and its abstinence in rhesus monkey / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 1802-1807, 2006.
Artículo
en Inglés
| WPRIM
| ID: wpr-335527
ABSTRACT
<p><b>BACKGROUND</b>Although dopamine transporter (DAT) is essential for addiction, the effect of additive drugs on DAT function is still controversial, especially for opiates. We investigated the functional changes of dopamine transporter in striatum of rhesus monkeys during acute morphine injection and its abstinence.</p><p><b>METHODS</b>Four rhesus monkeys, 6 to 9 years old, two male and two female, were examined for 12 days. Single photon emission computed tomography (SPECT) was performed with (99)T(cm)-TRODAT-1 as the radiopharmaceutical dopamine transporter agent during different stages of acute morphine injection and its abstinence. The ratios of SPECT signal between striatum and cerebellum (ST/CB) were calculated.</p><p><b>RESULTS</b>The ST/CB ratio declined significantly on the first day of morphine injection and continued declining with more morphine injections. After abstinence, the ratio increased with time, but was still significantly lower on the 5th day of abstinence than the normal level.</p><p><b>CONCLUSIONS</b>In rhesus monkey, acute morphine injection has both rapid and lasting effects on DAT by downregulating its function. The decline was partially reversible following morphine abstinence. The results suggest that striatum is one effective target of morphine and that the DAT function in striatum is one indicator for morphine addiction.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fisiología
/
Tropanos
/
Compuestos de Organotecnecio
/
Tomografía Computarizada de Emisión de Fotón Único
/
Cerebelo
/
Enfermedad Aguda
/
Cuerpo Estriado
/
Proteínas de Transporte de Dopamina a través de la Membrana Plasmática
/
Macaca mulatta
/
Metabolismo
Límite:
Animales
Idioma:
Inglés
Revista:
Chinese Medical Journal
Año:
2006
Tipo del documento:
Artículo
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