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Fractional Flow Reserve Guided Percutaneous Coronary Intervention Improves Clinical Outcome with Reduced Cost in Contemporary Clinical Practice / 中华医学杂志(英文版)
Chinese Medical Journal ; (24): 2000-2005, 2015.
Artículo en Inglés | WPRIM | ID: wpr-335669
ABSTRACT
<p><b>BACKGROUND</b>Fractional flow reserve (FFR) is currently considered as the gold standard for evaluating the functional significance of coronary stenosis. However, its potential benefits in real-world practice remain unknown in China. This study aimed to test the hypothesis that the use of FFR is associated with improved outcome and reduced cost in Chinese real-world clinical practice.</p><p><b>METHODS</b>A retrospective cohort study was carried out using the database of Second Affiliated Hospital of Zhejiang University, a tertiary and high-volume center in China. Clinical events were compared using the Cox proportional hazards model during a median follow-up of 13 months.</p><p><b>RESULTS</b>The study cohort consisted of 366 consecutive patients referred for coronary revascularization with adjunct FFR and 366 matched controls, from 2010 to 2014. Major adverse cardiac events (MACEs) (death, myocardial infarction, repeated revascularization, or hospitalization for angina) at 4 years were found in 12.0% of angiography-guided patients and 4.9% in the FFR-guided group (P < 0.001). The mean number of implanted stents was significantly lower in FFR treated subjects (0.52 ± 0.82 stents) compared with the angiography-guided group (0.93 ± 0.96 stents) (P < 0.001). No difference in overall costs at initial hospitalization was observed between angiography-guided percutaneous coronary intervention (PCI) compared with FFR-guided PCI (RMB 33,000 Yuan, range RMB 7393-44,700 Yuan) versus RMB 21,200 Yuan (RMB 19,100-47,100 Yuan) (P = 0.54). However, costs for MACEs during follow-up were significantly reduced in the FFR-guided arm (P < 0.001).</p><p><b>CONCLUSIONS</b>In the contemporary clinical practice, FFR-guided PCI is associated with decreased use of stents, improved clinical outcome, and reduced costs, compared with angiography-guided PCI.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Fisiología / China / Estudios Retrospectivos / Costos y Análisis de Costo / Economía / Reserva del Flujo Fraccional Miocárdico / Intervención Coronaria Percutánea / Métodos Tipo de estudio: Evaluación Económica en Salud / Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Anciano / Femenino / Humanos / Masculino País/Región como asunto: Asia Idioma: Inglés Revista: Chinese Medical Journal Año: 2015 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Fisiología / China / Estudios Retrospectivos / Costos y Análisis de Costo / Economía / Reserva del Flujo Fraccional Miocárdico / Intervención Coronaria Percutánea / Métodos Tipo de estudio: Evaluación Económica en Salud / Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Anciano / Femenino / Humanos / Masculino País/Región como asunto: Asia Idioma: Inglés Revista: Chinese Medical Journal Año: 2015 Tipo del documento: Artículo