Neuroprotective role of silent information regulator 1 in Alzheimer's disease / 生理学报
Acta Physiologica Sinica
;
(6): 396-400, 2011.
Artículo
en Chino
| WPRIM
| ID: wpr-335974
ABSTRACT
Silent information regulator 1 (SIRT1), an NAD(+)-dependent deacetylase, is involved in the regulation of gene transcription, energy metabolism and cell aging. Recent studies have showed that SIRT1 possesses neuroprotective effects, however, it is not very clear how SIRT1 exerts the neuroprotection in Alzheimer's disease (AD). In this review, we summarized the neuroprotective role of SIRT1 in AD and its possible molecular mechanisms, proposing a novel strategy for preventing and treating neurodegeneration.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fisiología
/
Transcripción Genética
/
Fármacos Neuroprotectores
/
Metabolismo Energético
/
Sirtuina 1
/
Enfermedad de Alzheimer
/
Genética
Límite:
Animales
/
Humanos
Idioma:
Chino
Revista:
Acta Physiologica Sinica
Año:
2011
Tipo del documento:
Artículo
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