Expressions of receptor-interacting protein and caspase-8 in oral squamous cell carcinoma and oral precancerous lesions / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1802-1805, 2009.
Artículo
en Chino
| WPRIM
| ID: wpr-336081
ABSTRACT
<p><b>OBJECTIVE</b>To detect the expressions of receptor-interacting protein (RIP) and caspase-8 and investigate their roles in oral squamous cell carcinoma (OSCC) and oral precancerous lesions.</p><p><b>METHODS</b>SABC immunohistochemical methods were used to detect the expressions of RIP and caspase-8 in 22 specimens of OSCC, 14 specimens of oral lichen planus (OLP), 14 specimens of oral leukoplakia (OLK) and 10 specimens of normal oral mucosa (NOM).</p><p><b>RESULTS</b>The rate of weak or negative expression of RIP in normal mucosa was 50% (5/10). The rates of weak and positive expression of RIP in OLP, OLK and OSCC were 75% (36/50), and the rate of positive and strong expression of RIP was 63.7% (14/22) in OSCC, significantly higher that in the others groups (P<0.05). The rates of weak, positive and strong positive expression of caspase-8 in NOM, OLP, OLK and OSCC were 80% (8/10), 100% (14/14), 85.7% (12/14), and 100% (22/22), respectively.</p><p><b>CONCLUSION</b>Both RIP and caspase-8 may play important roles in the occurrence and progression of OSCC and oral precancerous lesions.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Lesiones Precancerosas
/
Neoplasias de la Boca
/
Inmunohistoquímica
/
Carcinoma de Células Escamosas
/
Caspasa 8
/
Proteína Serina-Treonina Quinasas de Interacción con Receptores
/
Metabolismo
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Journal of Southern Medical University
Año:
2009
Tipo del documento:
Artículo
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