A clinical analysis of fetal chromosomal aberration induced by paint and hair dye / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To analyze the effect of long-term exposure to paint or hair dye on chromosomal aberration of early embryos.</p><p><b>METHODS</b>We analyzed 2 cases of fetal or infantile chromosome aberration in which the parents experienced long-term exposure to paint and hair dye.</p><p><b>RESULT</b>The chromosomal mutations were detected in one 3-month-old infant and one 21-week-old fetus, and the karyotypes were 46,XX,del(2)(pter'q31) and 46,XX, t(4;12;15), respectively. Their parents worked with long-term exposure to paint and hair dye and developed such symptoms as dizziness, headache, and insomnia. The chromosomes of the parents remained normal, but the micronuclei of the lymphocytes and plasma lead level were increased with decreased WBC, platelet, and HGB.</p><p><b>CONCLUSION</b>Long exposure to paint or hair dye can cause poison and affect the normal growth of early embryos, leading eventually to gene and chromosomal mutation of the embryos.</p>