Cytocompatibility of PBS/PLA blend as the sternal fixation material / 南方医科大学学报

ABSTRACT

<p><b>UNLABELLED</b>To evaluate biocompatibility and cytotoxicity of PBS/PLA blend as the material for sternal fixation.</p><p><b>METHODS</b>L929 cell line was used to assess the cytotoxicity and cytocompatibility of PBS/PLA blend by incubation of the cells with the aqueous extract of the material for 3 days. The cytocompatibility of the material was evaluated by observing the proliferation of the cells cultured on the surface of the material. The proliferation of the cells cultured on the surface of the material was compared with that of the cells cultured on medical polyethylene and polyvinyl chloride to assess the cytotoxicity of the material.</p><p><b>RESULTS</b>L929 cells showed no morphological changes after a 3-day incubation with the aqueous extract of the material. The cells cultured on the surface of the blend material exhibited better proliferative activity than those cultured on medical polyethylene and polyvinyl chloride, demonstrating no obvious cytotoxicity of the material.</p><p><b>CONCLUSION</b>PBS/PLA blend material possesses excellent cytocompatibility and can be a promising biodegradable polymer for sternal fixation.</p>