An analysis of the characteristics and etiology of hand, foot and mouth disease in a Guangzhou sentinel hospital from May to December, 2008 / 南方医科大学学报
Journal of Southern Medical University
; (12): 1333-1335, 2010.
Article
en Zh
| WPRIM
| ID: wpr-336186
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the characteristics and etiology of hand, foot and mouth disease (HFMD) in a sentinel hospital of Guangzhou.</p><p><b>METHODS</b>The epidemiological data and clinical specimens were collected from May to December, 2008 for virological investigations (viral isolation, RT-PCR and molecular identification) and phylogenetic analysis.</p><p><b>RESULTS</b>A total of 309 clinical cases were reported, and the incidence was the highest in 2-4-year-old children, among whom only 15 developed complications, with human enterovirus 71 (HEV71) as the main pathogen (64.7%). Phylogenetic analysis indicated that ten Guangzhou EV71 isolates belonged to Cluster C4a.</p><p><b>CONCLUSION</b>HFMD is an important infectious disease in children resulting from infections by HEV71 as the main pathogen in 2008, and the Guangzhou C4a strains co-evolved with the isolates from other provinces in China and the neighboring countries.</p>
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Virología
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China
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Epidemiología
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Incidencia
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Reacción en Cadena de la Polimerasa de Transcriptasa Inversa
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Enterovirus Humano A
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Enfermedad de Boca, Mano y Pie
Tipo de estudio:
Etiology_studies
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Incidence_studies
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Prognostic_studies
Límite:
Child, preschool
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Female
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Humans
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Male
País/Región como asunto:
Asia
Idioma:
Zh
Revista:
Journal of Southern Medical University
Año:
2010
Tipo del documento:
Article