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Ataxia-telangiectasia mutated gene and breast cancer susceptibility / 生物工程学报
Chinese Journal of Biotechnology ; (12): 9-15, 2010.
Artículo en Chino | WPRIM | ID: wpr-336268
ABSTRACT
Breast cancer is bound up with the environment. As a consequence of DNA damage induced by environmental carcinogens, a number of sophisticated sensing and transduction systems are initiated and the signal is conveyed simultaneously to multiple effectors. This process ultimately results in cancer. The protein kinase Ataxia-telangiectasia mutated (ATM) that encoded by ATM gene is the master regulator of DNA damage response. In this consecutive reaction, the protein kinase ATM responds to the DNA damage by phosphorylating a variety of downstream substrates, which plays an important role in the inhibition of the development of breast cancer. After ATM gene mutate, DNA damaged could not be accurately repaired and finally accelerates breast cancer transformation and proliferation. With the further research of ATM gene structure, function and breast cancer susceptibility, the extensive attention is paid to the relationship between ATM gene and breast cancer susceptibility. We reviewed the research advances in breast cancer susceptibility in several aspects of ATM gene, including mutation, polymorphism and methylation.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Polimorfismo Genético / Daño del ADN / Neoplasias de la Mama / Proteínas Serina-Treonina Quinasas / Proteínas de Ciclo Celular / Metilación de ADN / Predisposición Genética a la Enfermedad / Proteínas Supresoras de Tumor / Proteínas de Unión al ADN / Proteínas de la Ataxia Telangiectasia Mutada Límite: Femenino / Humanos Idioma: Chino Revista: Chinese Journal of Biotechnology Año: 2010 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Polimorfismo Genético / Daño del ADN / Neoplasias de la Mama / Proteínas Serina-Treonina Quinasas / Proteínas de Ciclo Celular / Metilación de ADN / Predisposición Genética a la Enfermedad / Proteínas Supresoras de Tumor / Proteínas de Unión al ADN / Proteínas de la Ataxia Telangiectasia Mutada Límite: Femenino / Humanos Idioma: Chino Revista: Chinese Journal of Biotechnology Año: 2010 Tipo del documento: Artículo