The effects of nicotine on bone calcium and phosphorus content and alkaline phosphatase activity in different part of rat / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 225-231, 2013.
Artículo
en Chino
| WPRIM
| ID: wpr-336352
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the effects of nicotine on the bone calcium and phosphorus content and alkaline phosphatase (ALP) activity in rat alveolar bone and mandible.</p><p><b>METHODS</b>Twenty health male Wistar rats of five weeks of age were randomly assigned to two groups and received daily intraperitoneal injections for three months as follows Saline solution for control group, nicotine 0.73 mg.kg-l.d-1 for experimental group. The bone calcium phosphorus content were detected by concentrated acid digestion method and the ALP activity was examined by improved Reddi method.</p><p><b>RESULTS</b>Compared to the control group, bone calcium and phosphorus content was lower in the experimental group (P<0.05), ALP activity had no statistical significance(P>0.05). Bone calcium phosphorus and ALP activity in different parts had no statistical significance (P>0.05).</p><p><b>CONCLUSION</b>The nicotine reduces calcium phosphorus deposition of jaw bone, but has no obvious influence to ALP activity.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fósforo
/
Huesos
/
Calcio
/
Ratas Wistar
/
Fosfatasa Alcalina
/
Nicotina
Límite:
Animales
Idioma:
Chino
Revista:
West China Journal of Stomatology
Año:
2013
Tipo del documento:
Artículo
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