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Serum citrulline: a potential marker for intestinal epithelial mass and absorption capacity in short bowel syndrome patients / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery ; (12): 333-337, 2007.
Artículo en Chino | WPRIM | ID: wpr-336452
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the potential role of serum citrulline level in evaluating the intestinal absorptive area and capacity in patients with short bowel syndrome (SBS).</p><p><b>METHODS</b>Serum citrulline concentration was determined using high performance liquid chromatography (HPLC) in SBS patients (n=22) and healthy controls (n=33). In SBS patients, the remnant small bowel lengths and diameters were measured by radiography, and their 5- hour urine D- xylose excretion and intestinal protein absorption were also determined. The correlationship of serum citrulline level with remnant small bowel length, surface area, protein and D- xylose absorption was analyzed. The 6 patients receiving intestinal rehabilitative therapy, serum citrulline level, protein and D- xylose absorption after therapy were also measured.</p><p><b>RESULTS</b>Serum citrulline level of SBS patients was significantly lower than that of healthy controls [(5.94+/- 2.65) vs [(16.87 +/- 5.97) micromol/L, P < 0.01]. In SBS patients, serum citrulline was positively correlated with remnant small bowel length and surface area (r=0.82 and r=0.86 respectively). There was also a significant correlationship of serum citrulline level with 5- hour D- xylose excretion (r=0.56) and intestinal protein absorption (r=0.48). Serum citrulline, 5- hour D- xylose excretion and intestinal protein absorption were all significantly raised in patients after rehabilitative therapy, although no correlation of increasing percentage was found among above three parameters.</p><p><b>CONCLUSIONS</b>Serum citrulline concentration is positively correlated with intestinal absorptive area and capacity in SBS patients. It is a potential marker for evaluating the severity of intestinal failure and the efficacy of rehabilitative therapy in short bowel patients.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Síndrome del Intestino Corto / Xilosa / Sangre / Estudios de Casos y Controles / Citrulina / Intestino Delgado / Metabolismo Tipo de estudio: Estudio observacional Límite: Adolescente / Adulto / Anciano / Femenino / Humanos / Masculino Idioma: Chino Revista: Chinese Journal of Gastrointestinal Surgery Año: 2007 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Síndrome del Intestino Corto / Xilosa / Sangre / Estudios de Casos y Controles / Citrulina / Intestino Delgado / Metabolismo Tipo de estudio: Estudio observacional Límite: Adolescente / Adulto / Anciano / Femenino / Humanos / Masculino Idioma: Chino Revista: Chinese Journal of Gastrointestinal Surgery Año: 2007 Tipo del documento: Artículo