Effect of p53 gene knockout on cell migration / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1132-1135, 2007.
Artículo
en Chino
| WPRIM
| ID: wpr-337313
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the role of p53 gene in serum-induced cell migration.</p><p><b>METHODS</b>The effects of p53 knockout on serum-induced formation of lamellipodia and cell migration were observed using Transwell cell migration system.</p><p><b>RESULTS</b>p53(+/+) cells developed lamellipodia upon serum stimulation and showed enhanced activity of cell migration, but these effects were not observed in p53 knockout cells after serum stimulation.</p><p><b>CONCLUSION</b>p53 plays a role in serum-induced cell migration.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Seudópodos
/
Línea Celular
/
Movimiento Celular
/
Regulación de la Expresión Génica
/
Proteína p53 Supresora de Tumor
/
Suero
/
Técnicas de Inactivación de Genes
/
Genética
/
Metabolismo
Límite:
Animales
Idioma:
Chino
Revista:
Journal of Southern Medical University
Año:
2007
Tipo del documento:
Artículo
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