Preliminary study of neuroendocrine differentiation and its mechanism in ovarian epithelial tumors / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1081-1083, 2007.
Artículo
en Chino
| WPRIM
| ID: wpr-337319
ABSTRACT
<p><b>OBJECTIVE</b>To investigate neuroendocrine differentiation and its mechanism in ovarian epithelial tumors.</p><p><b>METHODS</b>Neuroendocrine (NE) cells were identified by immunohistochemical staining for chromogranin A and synaptophysin in 79 cases of ovarian epithelial tumor and 22 cases of normal ovary. Double-labeling technique was used for simultaneous detection of CgA and epithelial membrane antigean (EMA), and the staining intensity was quantitatively evaluated using an image analysis system.</p><p><b>RESULTS</b>The positive staining rate for CgA and SYN in ovarian epithelial tumors was 59.4% and 65.36%, respectively, which was higher than that in normal ovary (P=0.000), in which numerous NE cells were found. Both the number and staining intensity of NE cells in ovarian epithelial tumor were increased as compared with normal ovary. Cells co-expressing CgA and EMA were detected in the ovarian epithelial tumors.</p><p><b>CONCLUSION</b>The presence of NE cells in ovarian epithelial tumor suggests heterogeneity of the tumors, and the occurrence of "multidirectional differentiation cells" within the these tumors indicates that NE cells might derive from malignant cells with multidirectional differentiation capacity.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Neoplasias Ováricas
/
Ovario
/
Patología
/
Inmunohistoquímica
/
Estudios de Casos y Controles
/
Regulación Neoplásica de la Expresión Génica
/
Diferenciación Celular
/
Neoplasias Glandulares y Epiteliales
/
Biología Celular
/
Células Neuroendocrinas
Tipo de estudio:
Estudio observacional
Límite:
Adulto
/
Anciano
/
Femenino
/
Humanos
Idioma:
Chino
Revista:
Journal of Southern Medical University
Año:
2007
Tipo del documento:
Artículo
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