Microsatellite analysis and hMLH1/hMSH2 expression detection in young patients with colorectal cancer: value in screening hereditary nonpolyposis colorectal cancer / 南方医科大学学报
Journal of Southern Medical University
;
(12): 779-782, 2007.
Artículo
en Chino
| WPRIM
| ID: wpr-337386
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the frequency of microsatellite instability (MSI) and absence of hMLH1/hMSH2 expression in young patients with colorectal cancer, and investigate their role in screening hereditary nonpolyposis colorectal cancer (HNPCC).</p><p><b>METHOD</b>Seventy-three young patients (below 40 years old) with colorectal cancer were examined for DNA mismatch repair deficiency by microsatellite testing and immunohistochemical detection of hMLH1/hMSH2 gene products.</p><p><b>RESULTS</b>The frequency of MSI and absence rate of hMLH1/hMSH2 expression are 56.16% and 49.32% in these patients, respectively, which increased significantly with younger age for cancer diagnosis.</p><p><b>CONCLUSION</b>Defects in the DNA mismatch repair system are frequent in Chinese young patients with colorectal cancer. Microsatellite analysis and immunohistochemical detection are useful for efficient identification of HNPCC in these young patients.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Inmunohistoquímica
/
Proteínas Nucleares
/
Neoplasias Colorrectales
/
Neoplasias Colorrectales Hereditarias sin Poliposis
/
Tamizaje Masivo
/
Repeticiones de Microsatélite
/
Proteínas Adaptadoras Transductoras de Señales
/
Diagnóstico
/
Proteína 2 Homóloga a MutS
Tipo de estudio:
Estudio diagnóstico
/
Estudio de tamizaje
Límite:
Adolescente
/
Adulto
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Journal of Southern Medical University
Año:
2007
Tipo del documento:
Artículo
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