Selective effect of nispex in inhibiting human cancer cell proliferation and inducing cell apoptosis / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 148-152, 2009.
Artículo
en Chino
| WPRIM
| ID: wpr-337529
ABSTRACT
<p><b>OBJECTIVE</b>To observe the in vitro anticancer effect of Nispex, the total flavonoids extract from Scurrula parasitic L.</p><p><b>METHODS</b>The cell proliferation inhibitory effects of Nispex on various kinds of tumor cells or non-tumor cells in human and rats were detected with MTT assay and colony forming assay respectively, the cell apoptosis induced by Nispex was detected by AO/EB fluorescence staining, TUNEL assay and AnnexinV-FITC/PI flow cytometry.</p><p><b>RESULTS</b>Nispex could significantly inhibit human cancer cell proliferation and induce human cancer cell apoptosis, especially to the proliferative cell group, but its inhibition on human non-tumor cell was insignificant, and showed no effect on murine cancer cells in the tested scope.</p><p><b>CONCLUSION</b>Nispex is a nature plant extract which shows good selectivity for killing human cancer cell.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Farmacología
/
Especificidad de la Especie
/
Flavonoides
/
Medicamentos Herbarios Chinos
/
Células Tumorales Cultivadas
/
Química
/
Apoptosis
/
Loranthaceae
/
Proliferación Celular
Límite:
Animales
/
Humanos
Idioma:
Chino
Revista:
Chinese Journal of Integrated Traditional and Western Medicine
Año:
2009
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS