Interleukin-1β inhibits the amplitudes of voltage-gated Na(+) currents and action potential in cultured cortical neurons of rat / 生理学报
Acta Physiologica Sinica
;
(6): 131-137, 2011.
Artículo
en Chino
| WPRIM
| ID: wpr-337694
ABSTRACT
Interleukin-1β (IL-1β) is an important proinflammatory cytokine and plays key roles in physiological and pathophysiological processes of central nervous system (CNS). The voltage-gated Na(+) channels are essential for electrical properties of excitable cells and control the excitability and action potential (AP) of neurons. Recent studies have showed the relationship between IL-1β and voltage-gated channels. In this work, cultured cortical neurons of rat were treated by 10 ng/mL of IL-1β for 24 h, and then voltage-gated Na(+) currents were recorded using voltage-clamp technique. The results indicated that IL-1β reduced the amplitude of Na(+) currents without any changes in activation or inactivation properties. The current-clamp recording showed that IL-1β reduced the amplitude of AP but not the threshold. These data indicate that IL-1β inhibits the voltage-gated Na(+) currents and the amplitude of AP, and suggest that essential roles of voltage-gated Na(+) channels may be changed by IL-1β. New information about effects of IL-1β on injuries and diseases of CNS was provided.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Fisiología
/
Potenciales de Acción
/
Células Cultivadas
/
Corteza Cerebral
/
Ratas Sprague-Dawley
/
Biología Celular
/
Interleucina-1beta
/
Canales de Sodio Activados por Voltaje
/
Neuronas
Límite:
Animales
Idioma:
Chino
Revista:
Acta Physiologica Sinica
Año:
2011
Tipo del documento:
Artículo
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