Effects of amyloid β-protein on hippocampal long-term potentiation / 生理学报
Acta Physiologica Sinica
;
(6): 479-488, 2010.
Artículo
en Chino
| WPRIM
| ID: wpr-337723
ABSTRACT
The accumulation of amyloid β-protein (Aβ) plaques is identified as a major pathological feature of Alzheimer's disease (AD). Recent studies show that soluble species of Aβ are involved in the early memory dysfunction long before neurodegenerative changes. However, the mechanism underlying the neurotoxicity of soluble Aβ is still unclear. Long-term potentiation (LTP) has been thought as an important cellular model of synaptic plasticity for many years. The studies on the hippocampal LTP and Aβ, especially those using AD transgenic models, provided more evidence for the Aβ-induced dysfunction of learning and memory. Based on the recent researches on AD, this article reviewed the effects of Aβ, especially soluble Aβ and its active fragments, on the hippocampal LTP. The possible mechanisms by which Aβ impairs hippocampal LTP are also discussed.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fisiología
/
Sinapsis
/
Péptidos beta-Amiloides
/
Potenciación a Largo Plazo
/
Enfermedad de Alzheimer
/
Hipocampo
/
Discapacidades para el Aprendizaje
/
Trastornos de la Memoria
/
Plasticidad Neuronal
Límite:
Animales
/
Humanos
Idioma:
Chino
Revista:
Acta Physiologica Sinica
Año:
2010
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS