Coexistence of tuberous sclerosis complex and malignant melanoma
Singapore medical journal
;
: e233-5, 2013.
Artículo
en Inglés
| WPRIM
| ID: wpr-337832
ABSTRACT
Tuberous sclerosis complex (TSC) is a multisystem genetic disorder characterised by widespread hamartomas in organs such as the skin, brain, heart, lung, liver and kidney. Although associations of TSC with hamartomas, angiomyolipomas and fibromas have been reported, there has been no report of its association with malignant melanoma. Herein, we describe a 31-year-old man with malignant melanoma associated with TSC. The patient had a history of epilepsia, multiple hypomelanotic macules, periungual fibromas and multiple hepatic lesions. Malignant melanoma was diagnosed by hepatic biopsy. To the best of our knowledge, this is the first report of malignant melanoma coexisting with TSC in the literature. We also present and discuss the imaging findings, prognosis, underlying mechanisms and practical approaches in relation to the disease.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Neoplasias Cutáneas
/
Terapéutica
/
Esclerosis Tuberosa
/
Biopsia con Aguja
/
Inmunohistoquímica
/
Imagen por Resonancia Magnética
/
Tomografía Computarizada por Rayos X
/
Estudios de Seguimiento
/
Medición de Riesgo
/
Enfermedades Raras
Tipo de estudio:
Estudio diagnóstico
/
Estudio de etiología
/
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Adulto
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Singapore medical journal
Año:
2013
Tipo del documento:
Artículo
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