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Assessment of efficacy-toxicity-syndrome correlation based on anti-inflammation of Sophorae Tonkinensis Radix et Rhizoma in excess-heat mice / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 2760-2764, 2015.
Artículo en Chino | WPRIM | ID: wpr-337894
ABSTRACT
Models of throat excess-heat mice were established and different dosages of water extract of STRR were ig given to mice to observe anti-inflammatory effect and its mechanism. The activities of ALT, AST and the contents of TNF-α, T3, rT3, T4, SOD, MDA, PEG2, NO, NOS, Cr, BUN, GSH and GSH-Px in serum were tested while liver index, kidney index, spleen index and thymus index were measured. The anti-inflammatory efficacy accompanied by side effects and mechanisms of water extract of Sophorae Tonkinensis Radix et Rhizoma (STRR) in excess-heat mice were investigated to clear safety dose-dependence range and the relationship of efficacy, toxicity and syndrome. In the experiment, water extract of STRR showed a strong inhibitory effect on ear edema by croton oil in throat excess-heat mice. The activities of ALT, AST in serum and liver index were all higher than that of normal group after multiple administration. PEG2, SOD, MDA, NO, NOS, GSH and GSH-Px had obvious changes. According to the results, water extract of STRR has an anti-inflammatory effect on acute inflammation in throat excess-heat mice and it is stronger than that in normal mice. The anti-inflammatory effect of STRR is related to the reduction of inflammatory mediators release. Side effects and hepatotoxicity will be produced on clinical efficacy dosage. The mechanisms of anti-inflammation and hepatotoxicity are all in connection with oxidative damnification.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Extractos Vegetales / Sophora / Rizoma / Usos Terapéuticos / Modelos Animales de Enfermedad / Toxicidad / Enfermedad Hepática Inducida por Sustancias y Drogas / Medicina Tradicional China / Fitoterapia / Antiinflamatorios Tipo de estudio: Estudio diagnóstico Límite: Animales Idioma: Chino Revista: China Journal of Chinese Materia Medica Año: 2015 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Extractos Vegetales / Sophora / Rizoma / Usos Terapéuticos / Modelos Animales de Enfermedad / Toxicidad / Enfermedad Hepática Inducida por Sustancias y Drogas / Medicina Tradicional China / Fitoterapia / Antiinflamatorios Tipo de estudio: Estudio diagnóstico Límite: Animales Idioma: Chino Revista: China Journal of Chinese Materia Medica Año: 2015 Tipo del documento: Artículo