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Comparative study on preparation of Polygoni Multiflori Radix based on hepatotoxic bioassay / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 2325-2329, 2015.
Artículo en Chino | WPRIM | ID: wpr-337936
ABSTRACT
Toxicity of different processed was evaluated Polygoni Multiflori Radix by determining the hepatotoxic potency for selecting processing technology. Process Polygoni Multiflori Radix using high pressure steamed, Black Bean high pressure steamed, atmospheric steamed for different time. Using normal human hepatocytes (L02) as evaluation model, hepatotoxic potency as index to evaluate hepatotoxic potency of different processed Polygoni Multiflori Radix. Analysis chemical composition of some processed products by UPLC-MS. Hepatotoxic bioassay method cloud evaluate the toxicity of different Polygoni Multiflori Radix samples. Different processing methods can reduce the toxicity of Polygoni Multiflori Radix, high pressure steamed three hours attenuated was better. Different processing methods have different effects on chemical constituents of Polygoni Multiflori Radix. Comparing with crude sample, the contents of gallic acid, 2,3,5,4-tetrahydroxyl diphenylethylene-2-O-glucoside, emodin-8-O-beta glucoside and emodin were decreased in processed products with 3 kinds of different methods. The change trend of 2,3,5,4-tetrahydroxyl diphenylethylene-2-O-glucoside content was similar with hepatotoxic potency. Different processing methods can reduce the toxicity of Polygoni Multiflori Radix. Processing methods and time attenuated obvious impact on toxicity. Recommended further research on the attehuated standard control of Polygoni Multiflori Radix concocted.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Bioensayo / Medicamentos Herbarios Chinos / Línea Celular / Química / Química Farmacéutica / Cromatografía Líquida de Alta Presión / Raíces de Plantas / Hepatocitos / Toxicidad / Fallopia multiflora Límite: Humanos Idioma: Chino Revista: China Journal of Chinese Materia Medica Año: 2015 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Bioensayo / Medicamentos Herbarios Chinos / Línea Celular / Química / Química Farmacéutica / Cromatografía Líquida de Alta Presión / Raíces de Plantas / Hepatocitos / Toxicidad / Fallopia multiflora Límite: Humanos Idioma: Chino Revista: China Journal of Chinese Materia Medica Año: 2015 Tipo del documento: Artículo