Study on material base of Ligusticum wallichii for treating brain ischemia and its molecular mechanism based on molecular docking / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2195-2198, 2015.
Artículo
en Chino
| WPRIM
| ID: wpr-337960
ABSTRACT
To explore the effective ingredients and mechanism of Ligusticum wallichii in treating brain ischemia. Four brain ischemia-related target proteins were selected in the joint screening for the 45 component in L. wallichii reported in literatures based on molecular docking by reference to the corresponding drugs in the market. According to the docking results, multiple components in L. wallichii, such as phthalides, were superior to the corresponding drugs in the market, suggesting that they may be the major effective components in L. wallichii for treating brain ischemia. The method can be used to study the material base and molecular mechanism of traditional Chinese medicines.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Isquemia Encefálica
/
Química
/
Factor de Necrosis Tumoral alfa
/
Peroxidasa
/
Ligusticum
/
Quimioterapia
/
Óxido Nítrico Sintasa de Tipo II
/
Simulación del Acoplamiento Molecular
/
Medicina Tradicional China
/
Fitoterapia
Tipo de estudio:
Estudio diagnóstico
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2015
Tipo del documento:
Artículo
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