Expression and implication of cyclooxygenase-2 mRNA in prostate cancer / 中华男科学杂志
National Journal of Andrology
;
(12): 159-161, 2006.
Artículo
en Chino
| WPRIM
| ID: wpr-338340
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between cyclooxygenase-2 (COX-2) mRNA expression and the biological behaviors of prostate carcinoma (PCa).</p><p><b>METHODS</b>The expression of COX-2 mRNA was detected by RT-PCR method in 32 samples of PCa and the COX-2/GAPDH value was determined. Seven normal prostate tissues were served as control.</p><p><b>RESULTS</b>The expression of COX-2 mRNA in normal tissue of 7 control cases was all negative. There was statistical correlation between the COX-2/GAPDH and the Gleason scores of PCa. There also showed statistical correlation between the COX-2/GAPDH and the stages of PCa.</p><p><b>CONCLUSION</b>COX-2 mRNA play an important role in occurrence and progression of the PCa. COX-2 is a tumor marker which may be the possible prognostic factor of PCa.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Pronóstico
/
Próstata
/
Neoplasias de la Próstata
/
ARN Mensajero
/
Estudios de Casos y Controles
/
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa
/
Ciclooxigenasa 2
/
Genética
/
Metabolismo
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
Límite:
Adulto
/
Anciano
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
National Journal of Andrology
Año:
2006
Tipo del documento:
Artículo
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