Clinical Significance of Multiple Serum Tumor Markers in the Detection of Ovarian Carcinoma / 대한산부인과학회잡지

ABSTRACT

OBJECTIVE: This study evaluated the possible role of 2 additional tumor markers to CA125 in discriminating between benign and malignant ovarian tumors. METHODS: Serum samples from 1,346 patients were obtained on seven days before operation. All patients underwent surgery for ovarian tumors. Serum levels of 3 tumor markers were compared to histology. Concentrations of tumor markers (CA125, CA72-4, CA19-9) were detected by enzyme immuno- or immunoradiometric assays. Normal range of these markers was defined as CA125 RESULTS: The average values (U/ml) of CA72-4 and CA19-9 in patients with malignant ovarian tumor were higher than those of benign ovarian tumor, respectively (12.09+/-32.36 vs. 2.09+/-5.43, 161.13+/-549.21 vs. 46.29+/-193.12). Among these 3 ovarian tumor markers, CA125 was the most sensitive (67.7%) marker and CA72-4 was the highest in specificity (96.3%).

CONCLUSION:

The checking the levels of CA72-4 and CA19-9 as the supplementary serum tumor markers additional to CA125 were more sensitive than CA125 alone in diagnosing ovarian carcinoma.