Dynamic change of serum protein S100b and its clinical significance in patients with traumatic brain injury / 中华创伤杂志(英文版)
Chinese Journal of Traumatology
;
(6): 245-248, 2005.
Artículo
en Inglés
| WPRIM
| ID: wpr-338604
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the dynamic change of serum protein S100b in patients with traumatic brain injury and its clinical value in assessing brain damage.</p><p><b>METHODS</b>According to Glasgow coma scale (GCS), 102 cases of traumatic brain injury were divided into mild brain injury group (GCS > or = 13, n = 31, Group A), moderate brain injury group (8 < GCS < 13, n = 37, Group B) and severe brain injury group (GCS < or = 8, n = 34, Group C). Serial S100b concentrations were analyzed by enzyme-linked immunosorbent assay (ELISA) in blood samples taken on admission, 12 h, 24 h, 48 h, 72 h and 7 days after traumatic brain injury.</p><p><b>RESULTS</b>The severe brain injury group showed significantly higher concentration of serum S100b, with earlier increase and longer duration, than the mild and moderate brain injury groups. The patients with higher S100b exhibited lower GCS scores and poor clinical prognosis. The increase in S100b could emerge before clinical image evidence indicated so.</p><p><b>CONCLUSIONS</b>Serum S100b can be used as a sensitive index for assessment and prediction of traumatic brain injury severity and prognosis.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Sangre
/
Lesiones Encefálicas
/
Ensayo de Inmunoadsorción Enzimática
/
Proteínas S100
/
Subunidad beta de la Proteína de Unión al Calcio S100
/
Factores de Crecimiento Nervioso
Tipo de estudio:
Estudio pronóstico
Límite:
Adolescente
/
Adulto
/
Anciano
/
Humanos
Idioma:
Inglés
Revista:
Chinese Journal of Traumatology
Año:
2005
Tipo del documento:
Artículo
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