Clinical application of perioperative continuous hyperthermic peritoneal perfusion chemotherapy for gastric cancer / 南方医科大学学报
Journal of Southern Medical University
;
(12): 295-297, 2009.
Artículo
en Chino
| WPRIM
| ID: wpr-339005
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the clinical effect of intraoperative and early postoperative continuous hyperthermic pertioneal perfusion chemotherapy (CHPPC) for gastric cancer.</p><p><b>METHODS</b>Eight-five patients with gastric cancer were randomized into therapeutic group with perioperative CHPPC combined with intravenous chemotherapy (n=44) and control group with intravenous chemotherapy only (n=41). The postoperative complications, adverse effects, local recurrence rates, distant metastasis rates, and 1- and 3-year survival rates were compared between two groups.</p><p><b>RESULTS</b>No significant differences were found in the postoperative complications and adverse effects between the two groups. The recurrence rate and distant metastasis rates in the therapeutic group were significantly lower than those in the control group (20.45% vs 43.90%, and 15.90% vs 39.02%, P<0.05). The 1- and 3-year survival rates in the therapeutic group were significantly higher than those in the control group (90.90% vs 78.05%, and 59.09% vs 34.15%, P<0.05).</p><p><b>CONCLUSION</b>Perioperative CHPPC for gastric cancer is safe and feasible, and can reduce the recurrence rate, distant metastasis rate and improve the survival for gastric cancer patient after operation.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Neoplasias Gástricas
/
Cirugía General
/
Quimioterapia del Cáncer por Perfusión Regional
/
Protocolos de Quimioterapia Combinada Antineoplásica
/
Resultado del Tratamiento
/
Adenocarcinoma Mucinoso
/
Quimioterapia
/
Hipertermia Inducida
/
Inyecciones Intraperitoneales
/
Periodo Intraoperatorio
Tipo de estudio:
Ensayo Clínico Controlado
Límite:
Adulto
/
Anciano
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Journal of Southern Medical University
Año:
2009
Tipo del documento:
Artículo
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