Survivin and COX-2 expressions in giant cell tumor of bone and their relation to the prognosis / 南方医科大学学报
Journal of Southern Medical University
;
(12): 156-159, 2009.
Artículo
en Chino
| WPRIM
| ID: wpr-339040
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of survivin and COX-2 in giant cell tumor of bone (GCT) and explore the prognostic factors for GCT.</p><p><b>METHODS</b>The expressions of survivin and COX-2 in 39 GCT tissues of three Jaffe grades and 4 normal bone tissues were detected by immunohistochemical staining, and the data were analyzed in relation to the clinicopathological features of the patients.</p><p><b>RESULTS</b>The expressions of survivin and COX-2 were significantly higher in the GCT tissues than in normal bone tissues (P<0.01). A positive correlation was found between survivin and COX-2 expressions and the pathological grade (P<0.01), but their expressions were not correlated to the patients' gender, age or surgical approaches (P>0.05). An obviously lowered recurrence rate was observed in patients with resection of the bone segment compromised by the tumor and subsequent bone grafting. Survivin and COX-2 were not independent risk factors of the prognosis of GCT.</p><p><b>CONCLUSION</b>Survivin and COX-2 expressions may participate in the pathogenesis and development of GCT, but is not indicative of the prognosis.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Pronóstico
/
Neoplasias Óseas
/
Tumor Óseo de Células Gigantes
/
Ciclooxigenasa 2
/
Proteínas Inhibidoras de la Apoptosis
/
Genética
/
Metabolismo
/
Proteínas Asociadas a Microtúbulos
Tipo de estudio:
Estudio pronóstico
Límite:
Adolescente
/
Adulto
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Journal of Southern Medical University
Año:
2009
Tipo del documento:
Artículo
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