Role of CD4+CD25+Foxp3+ regulatory T cells in type 2 diabetic nephropathy / 南方医科大学学报
Journal of Southern Medical University
; (12): 137-139, 2009.
Article
en Zh
| WPRIM
| ID: wpr-339045
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the role of CD4+CD25+Foxp3+ regulatory T cells (Treg) in type 2 diabetic nephropathy and provide new clues for prevention and treatment of type 2 diabetic nephropathy.</p><p><b>METHODS</b>Flow cytometry was used to analyze the expression rate of CD4+CD25+Foxp3+ Treg cells in 60 patients with type 2 diabetes and 15 normal subjects.</p><p><b>RESULTS</b>No significant difference was found in the expression rate of CD4+CD25+Foxp3+ Treg cells between the control group and the type 2 diabetic patients. In the type 2 diabetic patients with microalbuminuria and macroalbuminuria, the expression of CD4+CD25+Foxp3+ Treg cells was significantly lowered in comparison with that in the control group (P<0.05), and patients with macroalbuminuria showed significantly lower expression of CD4+CD25+Foxp3+ Treg cells than the microalbuminuric patinets (P<0.05). Significant inverse correlations were noted between the disease course and the expression of CD4+CD25+Foxp3+ Treg cells and between the urinary albumin excretion rate (UAER) and the expression of CD4+CD25+Foxp3+ Treg cells.</p><p><b>CONCLUSION</b>CD4+CD25+Foxp3+ Treg cells may play a role in the occurrence and development of type 2 diabetic nephropathy.</p>
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Antígenos CD4
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Estudios de Casos y Controles
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Subgrupos de Linfocitos T
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Linfocitos T Reguladores
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Diabetes Mellitus Tipo 2
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Nefropatías Diabéticas
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Alergia e Inmunología
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Factores de Transcripción Forkhead
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Subunidad alfa del Receptor de Interleucina-2
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Citometría de Flujo
Tipo de estudio:
Observational_studies
Límite:
Adult
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Aged
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Journal of Southern Medical University
Año:
2009
Tipo del documento:
Article