Expression of Aurora-B in human glioma tissue and its significance / 南方医科大学学报
Journal of Southern Medical University
; (12): 47-49, 2009.
Article
en Zh
| WPRIM
| ID: wpr-339069
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the expression of Aurora-B in human glioma tissue and its significance.</p><p><b>METHODS</b>The total RNA was extracted from 41 human glioma tissues and 11 normal brain tissues by Trizol reagent. After reverse transcription of the total RNA into cDNAs, Aurora-B mRNA expressions in these samples were detected by quantitative real-time PCR. The protein expression in these samples was detected using immunohistochemical staining.</p><p><b>RESULTS</b>Aurora-B mRNA and protein expressions were significantly increased in glioma tissues as compared with those in normal brain tissues.</p><p><b>CONCLUSION</b>Aurora-B mRNA and protein show markedly higher expressions in glioma tissue, suggesting that Aurora-B may be one of the malignant biomarkers in the pathogenesis and progression of human glioma.</p>
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Índice:
WPRIM
Asunto principal:
Patología
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Neoplasias Encefálicas
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ARN Mensajero
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Células Tumorales Cultivadas
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Biomarcadores de Tumor
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Proteínas Serina-Treonina Quinasas
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Aurora Quinasas
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Aurora Quinasa B
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Genética
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Glioma
Límite:
Female
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Humans
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Male
Idioma:
Zh
Revista:
Journal of Southern Medical University
Año:
2009
Tipo del documento:
Article