Liver histological changes after lamivudine treating in chronic hepatitis B patients with HBeAg positive / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 555-557, 2003.
Artículo
en Chino
| WPRIM
| ID: wpr-339178
ABSTRACT
<p><b>OBJECTIVES</b>To investigate the histological changes in liver biopsy tissues taken from chronic hepatitis B patients with HBsAg and HBeAg positive and ALT abnormal after lamivudine therapy for one year.</p><p><b>METHODS</b>Lamivudine was given orally at the dose of 100 mg once a day for one year. 101 patients were enrolled into this open-label study. Paired liver biopsies from patients with hepatitis B before and after therapy with lamivudine were studied. Blinded biopsies were evaluated by a histopathologist and scored according to Knodell's histology activity index(HAI).</p><p><b>RESULTS</b>53.5% (54/101), 51.5% (52/101) and 31.7% (32/101) patients had a reduction of their total hepatic HAI score, necroinflammation and fibrosis scores by >or=2 points or 1 points at the end of one year of lamivudine therapy, compared with their pretreatment values, respectively. There were significant reduction of HAI score, necroinflammation and fibrosis scores from 8.0+/-4.7 to 5.2+/-3.3 (t=7.358, P<0.01), from 5.9+/-3.8 to 3.6+/-2.5 (t=7.298, P<0.01), and from 2.1+/-1.2 to 1.6+/-1.2 (t=3.827, P<0.01), respectively. The histological improvement was independent on the HBeAg seroconvertion during the therapy.</p><p><b>CONCLUSION</b>Significant improvement in liver histology, both necroinflammation and fibrosis, can be obtained in the majority of patients treated with lamivudine for one year.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Antivirales
/
Patología
/
Lamivudine
/
Hepatitis B Crónica
/
Usos Terapéuticos
/
Quimioterapia
/
Antígenos e de la Hepatitis B
/
Hígado
/
Cirrosis Hepática
Límite:
Adolescente
/
Adulto
/
Niño
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Hepatology
Año:
2003
Tipo del documento:
Artículo
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