Dynamic changes and significance of antithrombin and fibrinolytic function in advanced lung cancer patients during chemotherapy / 中国肺癌杂志

ABSTRACT

<p><b>BACKGROUND</b>The prethrombotic state can be observed in advanced lung cancer patients. The aim of this study is to determine the dynamic changes and significance of antithrombin and fibrinolytic function in advanced lung cancer patients during chemotherapy.</p><p><b>METHODS</b>Antithrombin activity (ATA), fibrinogen (FIB), D-dimer (D-D), plasminogen activity (PLG), tissue plasminogen activator antigen (t-PAAg) and plasminogen activator inhibitor-1 antigen (PAI-1Ag) were measured in 33 advanced lung can-cer patients before and after chemotherapy, and 30 healthy people as controls.</p><p><b>RESULTS</b>Before chemotherapy, lung cancer patients had significantly lower ATA (P < 0.01) and higher D-D, PLGA, PAI-1Ag and FIB (P < 0.01) than those of controls. There was no significant difference in t-PAAg between lung cancer patients and controls (P > 0.05). During the chemotherapy, ATA, D-D and t-PAAg of lung can-cer patients remarkably decreased (P < 0.01), and PLGA, PAI-1Ag and FIB remarkably increased (P < 0.01) compared to those before chemotherapy.</p><p><b>CONCLUSIONS</b>Chemotherapy may enhance the prethrombotic state in advanced lung cancer patients. Dynamic observation of antithrombin and fibrinolytic function during chemotherapy might be useful for preventing pulmonary hemorrhage and pulmonary infarct and estimating prognosis of those patients.</p>