The relaxation effects of six extracts from Chinese herbs on the corpus cavernosum tissue of rabbit in vitro / 中华男科学杂志
National Journal of Andrology
;
(12): 793-799, 2005.
Artículo
en Chino
| WPRIM
| ID: wpr-339424
ABSTRACT
<p><b>OBJECTIVE</b>To study the relaxants effects of six extractions from Chinese Herbs (neferine, tetrandrine, kakonein, scutellarin, ginsenoside Rgl and ginsenoside Rb1) on the corpus cavernosum tissue of rabbit in vitro.</p><p><b>METHODS</b>Isolated stripes of rabbit corpus cavernosum tissue were precontracted with 10(-5) mol/L phenylephrine (PE). Relaxation in response to cumulative doses of six extracts at (10(-8) - 10(-3)) mol/L was determined.</p><p><b>RESULTS</b>On rabbit cavernosal muscle stripes precontracted with PE, neferine, tetrandrine, kakonein and scutellarin showed dose dependent relaxation. IC50 values were 4.60 x 10(-6), 3.73 x 10(-5), 8.03 x 10(-4) and 3.33 x 10(-3) mol/L, respectively. However, in the meantime, it was found that the relaxant effects of ginsenoside Rgl and ginsenoside Rbl less significant to stripes precontracted with PE. When the final concentration was 10(-3) mol/L, the relaxations were only (16.32 +/- 5.45)% and (11.21 +/- 3.10)%.</p><p><b>CONCLUSION</b>Among the six extracts which showed relaxant effects to rabbit cavernosal muscle stripes precontracted with PE, neferine had greater functions than the other five extracts.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pene
/
Farmacología
/
Fisiología
/
Técnicas In Vitro
/
Medicamentos Herbarios Chinos
/
Relación Dosis-Respuesta a Droga
/
Contracción Muscular
Límite:
Animales
Idioma:
Chino
Revista:
National Journal of Andrology
Año:
2005
Tipo del documento:
Artículo
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