Effect of large-dosage of 5alpha-reductase inhibitors on the spermatogenesis of male rats / 中华男科学杂志
National Journal of Andrology
; (12): 652-654, 2005.
Article
en Zh
| WPRIM
| ID: wpr-339459
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To identify the role of 5alpha-reductase in the spermatogenesis of male rats by studying the effect of two 5alpha-reductase inhibitors, Epristeride and Finasteride, on the spermatogenesis in male Sprague-Dawley (SD) rats.</p><p><b>METHODS</b>Changes in the weight of the testis, serum testosterone and dihydrotestosterone levels, epididymal sperm count, and reproductive function were observed and analyzed after the two 5alpha-reductase inhibitors were administered to male SD rats orally.</p><p><b>RESULTS</b>The experiment showed that in comparison with control animals, both the two 5alpha-reductase inhibitors: 1. suppressed the development of the prostate and reduced the weight of the testis in the experimental groups (P < 0.05); 2. decreased the serum level of dihydrotestosterone and enhanced testosterone; 3. inhibited epididymal sperm count and productive function.</p><p><b>CONCLUSION</b>High dosages of the 5alpha-reductase inhibitor, Epristeride, can suppress the development of the prostate and reduce the weight of the testis, decrease dihydrotestosterone, and inhibit spermatogenesis and productive function in male rats.</p>
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Farmacología
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Espermatogénesis
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Ratas Sprague-Dawley
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Finasterida
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Relación Dosis-Respuesta a Droga
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Inhibidores de 5-alfa-Reductasa
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Androstadienos
Límite:
Animals
Idioma:
Zh
Revista:
National Journal of Andrology
Año:
2005
Tipo del documento:
Article