The effect of restrained stress on cardiac myocyte apoptosis in rats and Chinese herbs yixinning interference on it / 中国应用生理学杂志

ABSTRACT

<p><b>AIM</b>To discuss the effects of restrained stress on cardiac myocyte apoptosis of rats in the whole body, and the effect of anti-stress-induced cardiac myocyte injury treated by Chinese herbs yixinning.</p><p><b>METHODS</b>Agarose gel electrophoresis and TUNEL are used to detect cardiac myocyte apoptosis.</p><p><b>RESULTS</b>(1) When restrained stress 1,2,4 week, the DNA ladder of stress groups was negative, while in situ apoptosis of stress groups increased apparently compared with control group (P < 0.01). (3) The DNA ladder of yixinning groups was negative too, while in situ apoptosis of yixinning groups decreased compared with stress group (P < 0.05). (3) Whereas in distilled water group, the above indices had no statistical significance compared with stress model group (P > 0.05).</p><p><b>CONCLUSION</b>The restrained stress can induce cardiac myocyte apoptosis in rats. Chinese herbs "yixnning" can inhibit cardiac myocyte apoptosis, and have functions of anti-stress injury.</p>